Placental Tissue Matrix Allograft (PTM) is a product that has been proven to replace damaged tissue, control inflammation and pain, support the regenerative process, and reduce scar tissue formation. Placental tissues have been used in tens of thousands of procedures in the use over the past two decades. PTM® comes from the placenta of female volunteers from California, donated after their successful C-sections. There are no tissues from the mother or from the baby.
PTM® contains the following:
• Scaffold Components2
• Collagen 1, III, IV, V, and V1, hyaluronan, fibronectin, laminins
• Growth Factors3
• Fibroblast (bFGF), Epidermal (EGF), Keratinocyte (KGF), Platelet-derived AA (PDGF-AA), Platelet-Derived BB (PDGF-BB), Transforming-a (TGF-a), Transforming-b1 (TGF-b1), Transforming-b2 (TGF-b2), Transforming-b3 (TGF-b3), and Vascular Endothelial (VEGF)
• Metalloproteinases (MMP) Inhibitors4
• Tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2, TIMP-4)
• Interleukins (Il-04 and Il-10)
PTM is an alternative to PRP to regenerate and heal injured tendons, ligaments, fascia, and nerves of the shoulders, hips, knees, ankles, feet, and hands. PTM is equally, if not more, effective than PRP or Stem Cells, and contains more growth factors per unit volume. PTM is excellent for patients whose own blood is not safe for autologous treatments (i.e. Stem Cell or PRP), such as geriatric patients, patients who smoke, or patients with cancer. Additionally, PTM does not cause such a flare-up of pain post procedure. PTM can be injected into the spine to reverse the breakdown and stimulate the healing and regeneration of arthritic joints. In fact, regenerative medicine providers choose PTM over PRP or stem cell therapy for spinal dejenerative joint disease because it has proven to be more efficacious than stem-cell or PRP. PTM is used more commonly in the small and large joints and tendons of the body, often with superior results to PRP.
The cost per milliliter is higher for PTM than PRP, so the medical provider will help the patient to understand the quantity needed for the patient’s specific injury or pathology. Patients often choose PTM because they do not have to receive a blood draw but can walk into the office and have the PTM pulled off the shelf and injected on the same day. The choice to use PTM or PRP is based on a variety of factors, and can be determined through a consultation with the regenerative medicine provider.
PTM procedures are delicate. It is important that the growth factors, collagens, proteins and bioactive molecules stay in the area they are injected. Excessive motion of the joint will push the cells out of the area. The best results are attained by initially limiting motion of the joint or area injected. This allows the body to heal optimally.
PTM healing time: 50-75% improvement in 2-8 weeks, 100% in 3-6 months.